Sugar-sweetened drinks tied to CKD risk

  • Rebholz CM & al.
  • Clin J Am Soc Nephrol
  • 27 Dec 2018

  • curated by Yael Waknine
  • Clinical Essentials
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  • A pattern of higher consumption of sugar-sweetened beverages is linked to higher odds of chronic kidney disease (CKD).

Why this matters

  • Findings contribute to a growing body of evidence pointing to negative consequences of consuming soda and other sweetened beverages.

Study design

  • Analysis of data for 3003 black individuals (mean age, 54±12 years; 64% women) participating in the prospective, community-based Jackson Heart Study.
  • Beverage intake assessed at baseline using a food frequency questionnaire.
  • Funding: Jackson Heart Study funded by National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities.

Key results

  • Mean baseline estimated glomerular filtration rate (eGFR) (in mL/minute/1.73 m2), 98.
  • Over a median follow-up of 8 years, 185 participants (6%) developed incident CKD, defined as eGFR
  • In multivariate analysis, principal component analysis-derived pattern consisting of a higher consumption of soda, sweetened fruit drinks, and water was tied to 61% higher odds of CKD (aOR for third vs first tertile, 1.61; 95% CI, 1.07-2.41).
    • Analysis adjusted for total energy intake, age, sex, education, BMI, smoking, physical activity, hypertension, diabetes, cholesterol, cardiovascular disease history, and baseline eGFR.
  • Association was stronger for consumption pattern rather than individual drinks within that pattern.


  • Self-reported dietary intake.
  • Potentially nongeneralizable.

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