- A single-center analysis reveals an excellent prognosis with surgery, even in the presence of liver metastases, among patients with solid pseudopapillary neoplasm of the pancreas (SPN).
Why this matters
- Due to its rarity, the natural history of SPN has not been thoroughly studied.
- Retrospective analysis of 243 cases at a single center (2 with synchronous liver metastases).
- Funding: National Natural Science Foundation of China, Shanghai Sailing Program, National Science Foundation for Distinguished Young Scholars of China.
- 74.5% of patients were female. Mean age, 35.3 years.
- All patients underwent surgical resection, including pancreaticoduodenectomy (Whipple, 20.6%), pylorus-preserving pancreaticoduodenectomy (4.5%), distal pancreatectomy with splenectomy (52.3%), spleen-preserving distal pancreatectomy (9.1%), central pancreatectomy (6.6%), tumor enucleation (3.7%), total pancreatectomy resection (1.2%), and resection of retroperitoneum tumor (0.4%).
- During a median follow-up of 46 (range, 10-118) months, 4 patients had a recurrence, which included the 2 subjects with liver metastases. 2 underwent reoperation, and 2 refused and later succumbed to tumor progression.
- Survival was 100% at 1 year, 99.6% at 3 years, and 98.4% at 5 years.
- Single center.