Sustained weight loss is linked to lower risk for postmenopausal breast cancer

  • Teras LR & al.
  • J Natl Cancer Inst
  • 13 Dec 2019

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Sustained weight loss in women age ≥50 years was associated with up to 32% lower risk for postmenopausal breast cancer in a pooled analysis.

Why this matters

  • Excess body weight has long been tied to breast cancer risk, but this study is the first to assess the effect of sustained weight loss in breast cancer risk reduction.
  • Findings suggest that postmenopausal women with overweight or obesity should be encouraged to lose weight.

Study design

  • Prospective observational study pooling 10 cohorts (United States, Australia, Asia) of women age ≥50 years in the Pooling Project of Prospective Studies of Diet and Cancer (n=180,885).
  • Weight was assessed in 2 intervals over a 10-year period, and breast cancer incidence was determined in a follow-up period over the next 8 years.
  • Sustained weight loss was defined as ≥2 kg lost in interval 1 that was not regained in interval 2.
  • Funding: NIH; Australian National Health and Medical Research Council; others.

Key results

  • Women with sustained weight loss vs stable weight and not using postmenopausal hormone had a linear reduction in breast cancer risk (HRs; 95% CIs):
    • >2-4.5 kg lost: 0.82 (0.70-0.96);
    • >4.5-
    • ≥9 kg lost: 0.68 (0.50-0.93).

Limitations

  • Observational design.