Systemic sclerosis: high prevalence of neuropathic pain often overlooked

  • Cuzdan N & al.
  • Clin Rheumatol
  • 24 Apr 2018

  • curated by Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • Neuropathic pain (NP) has a prevalence of 35.9% in patients with systemic sclerosis (SSc).
  • This is the first published report of its prevalence.

Why this matters

  • NP is frequently overlooked.
  • It needs to be evaluated and treated separately from traditional, non-NP.

Study design

  • Cross-sectional cohort of 120 patients with SSc who had been diagnosed with American College of Rheumatology 2013 criteria and followed for at least 1 year.
  • NP was assessed by The Leeds Assessment of Neuropathic Symptoms and Signs (LANNS) questionnaire, pain was assessed by visual analog scale (VAS), and QoL was assessed by Short-Form 36.
  • Funding: None disclosed.

Key results

  • 69.2% of cohort reported pain of any type (by VAS).
  • 35.9% of cohort reported NP (by LANNS).
  • Pain was most common in the wrist-hand (50.6%), whereas NP was most common in the face (94.4%), lower leg (87.5%), and hip-thigh (78.6%).
  • QoL was lower in patients with NP than those without NP (P<.05>

Limitations

  • No control group.

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