- Younger age, lymphovascular invasion (LVI), mitotic rate, thickness, location, and Clark level are associated with sentinel lymph node (SLN) metastasis in patients with T2 melanoma.
Why this matters
- Accurate prediction of metastasis risk can help avoid unnecessary SLN biopsy, particularly among elderly patients with low-risk disease.
- Increasing thickness (OR, 1.009; P<.0001 lvi p mitotic rate>2 (OR, 1.77; P<.0001 and clark level p=".0046)" were associated with sln metastasis in multivariate analysis.>
- Older age (OR, 0.977; P<.0001 and extremity location p=".0010" vs axial were inversely associated.>
- This group comprised 60% of the patients in the data set.
- 12,918 patients with clinically node-negative T2 melanoma who underwent SLN biopsy from the National Cancer Database were included.
- Funding: None disclosed.
- Observational study of large database.