T2DM tied to CRC risk in men, but not women

  • Br J Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Type 2 diabetes mellitus (T2DM) was associated with a significant increase in colorectal cancer (CRC) risk in men, but only a modest, nonsignificant increase in women.

Why this matters

  • Although studies suggest a link between T2DM and CRC risk, there is little data on the effect of duration or gender.

Study design

  • 87,523 women from the Nurses’ Health Study and 47,240 men from the Health Professionals Follow-up Study.
  • Funding: None.

Key results

  • 3000 cases of CRC (1790 in women, 1210 in men) during 3,547,837 person-years of follow-up.
  • Among patients with CRC, 159 women and 81 men had T2DM.
  • In men, T2DM was associated with increased risk for incident colorectal cancer in multivariate analysis (aHR, 1.42; 95% CI, 1.12-1.81).
    • The association was still evident after excluding CRC cases diagnosed within 1 year of T2DM diagnosis (aHR, 1.40; 95% CI, 1.10-1.78).
  • Among women, T2DM showed only a slight, nonstatistically significant association with CRC risk (HR, 1.17; 95% CI, 0.98-1.39).
  • CRC risk did not vary by T2DM duration in either men or women.

Limitations

  • Limited data on diabetes treatment or glucose control.

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