TAVR is safe for intermediate-risk patients

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  • Transcatheter aortic valve replacement (TAVR) is safe in patients with severe aortic stenosis (AS) at intermediate surgical risk, with similar rates of mortality and disabling stroke at 2 y as surgical aortic valve replacement (SAVR).
  • TAVR patients had more major bleeding, major vascular complications, and permanent pacemaker (PPM) implantation and SAVR patients had more acute kidney injury (AKI) and atrial fibrillation (Afib).

Why this matters

  • Although TAVR has been studied extensively in high-risk patients, randomized studies of intermediate-risk patients were lacking.

Study design

  • Surgical Replacement and Transcatheter Aortic Valve Implantation noninferiority, multicenter, randomized trial.
  • 1657 patients with severe AS at intermediate surgical risk underwent...