- Among known cardiovascular disease (CVD) risk factors, higher adiposity was most closely tied to venous thromboembolism (VTE) in this large study.
- Current alcohol consumption showed a protective effect in 2 separate populations.
Why this matters
- CVD and VTE share risk factors.
- 2 populations examined: Emerging Risk Factors Collaboration (ERFC) and UK Biobank.
- Among the CVD factors included, the following were associated with increased VTE risk (HRs; 95% CIs) for ERFC and Biobank cohorts, respectively:
- Per decade of age: 2.67 (2.45-2.91) and 1.81 (1.71-1.92).
- Current smoker: 1.38 (1.20-1.58) and 1.23 (1.08-1.40).
- Each 1 standard deviation increase in BMI: 1.43 (1.35-1.50) and 1.37 (1.32-1.41).
- Adiposity showed the closest association with VTE.
- Results for BP or diabetes were mixed.
- Alcohol was tied to decreased VTE risk in both cohorts (HRs; 95% CIs):
- ERFC: 0.75 (0.61-0.93).
- Biobank: 0.82 (0.71-0.94).
- 2 populations:
- ERFC: n=731,728; 75 cohorts; baseline surveys February 1960-June 2008; last follow-up, December 2015.
- UK Biobank: n=421,537; baseline surveys, March 2006-September 2010; last follow-up, February 2016.
- Outcomes: HR for each standard deviation increase over usual risk factor levels.
- Funding: UK Medical Research Council, other government and foundation.
- EFRC data did not routinely include non-CVD-related VTE risk factors.