These CVD risk factors are most closely tied to VTE risk

  • Gregson J & al.
  • JAMA Cardiol
  • 16 Jan 2019

  • curated by Emily Willingham, PhD
  • Clinical Essentials
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Takeaway

  • Among known cardiovascular disease (CVD) risk factors, higher adiposity was most closely tied to venous thromboembolism (VTE) in this large study.
  • Current alcohol consumption showed a protective effect in 2 separate populations.

Why this matters

  • CVD and VTE share risk factors.

Key results

  • 2 populations examined: Emerging Risk Factors Collaboration (ERFC) and UK Biobank.
  • Among the CVD factors included, the following were associated with increased VTE risk (HRs; 95% CIs) for ERFC and Biobank cohorts, respectively:
    • Per decade of age: 2.67 (2.45-2.91) and 1.81 (1.71-1.92).
    • Current smoker: 1.38 (1.20-1.58) and 1.23 (1.08-1.40).
    • Each 1 standard deviation increase in BMI: 1.43 (1.35-1.50) and 1.37 (1.32-1.41).
  • Adiposity showed the closest association with VTE.
  • Results for BP or diabetes were mixed.
  • Alcohol was tied to decreased VTE risk in both cohorts (HRs; 95% CIs):
    • ERFC: 0.75 (0.61-0.93).
    • Biobank: 0.82 (0.71-0.94).

Study design

  • 2 populations:
    • ERFC: n=731,728; 75 cohorts; baseline surveys February 1960-June 2008; last follow-up, December 2015.
    • UK Biobank: n=421,537; baseline surveys, March 2006-September 2010; last follow-up, February 2016.
  • Outcomes: HR for each standard deviation increase over usual risk factor levels.
  • Funding: UK Medical Research Council, other government and foundation.

Limitations

  • EFRC data did not routinely include non-CVD-related VTE risk factors.

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