- A third dose of measles-mumps-rubella (MMR) vaccine increases antibody levels in young adults and may protect against mumps for longer periods of time than previously believed.
Why this matters
- Findings bolster Advisory Committee on Immunization Practices recommendations for at-risk persons during outbreaks.
- MMR booster might also boost waning immunity for up to 1 year.
- 134 participants; age, 18-25 years.
- With IgG cutoff of 102 RU/mL, 80.9% of participants were protected prebooster, increasing to 93.9% 4 weeks postbooster (P=.001), leveling off at 91.3% at 1 year (P=.026).
- Roughly 77.6% had immunity (ND50 titer>34) against mumps prebooster, increasing to 85.7% (P<.0001 at weeks year respectively.>
- For outbreak strain specifically (ND50 titer>26), 78.2% were protected prebooster, increasing to 88.4% (P=.001), 88.8% (P<.0001 weeks year respectively.>
- Prospective, interventional Dutch study assessing the value of third MMR vaccine dose to boost immunity in outbreak scenarios.
- Funding: Dutch Ministry of Health, Welfare and Sport.
- Discrimination bias.
- Vaccine schedule differs from U.S.