Thyroid cancer: extensive ETE tied to greater recurrence risk in T4a disease

  • Abraham E & al.
  • J Surg Oncol
  • 26 Aug 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Extensive extrathyroidal extension (ETE) is associated with increased risk of recurrence in patients with T4a papillary thyroid cancer (PTC).

Why this matters

  • Identification of prognostic markers can help with treatment planning.

Key results

  • Extensive ETE (multiple structures involved) was associated with increased risk of recurrence compared with limited ETE (single structure involved).
    • HR, 5.1; P=.030 in analysis adjusted for radioactive iodine treatment.
    • HR, 4.7; P=.041 in analysis adjusted for margin status.
    • HR, 8.3; P=.034 in analysis adjusted for primary tumor size.
  • Microscopic positive margins (HR, 4.1; P=.041) and age ≥55 years (HR, 4.3; P=.042) were also associated with increased risk of recurrence (univariate analysis).
  • Low-risk patients (limited ETE, clear margins,

Study design

  • 39 patients with T4a PTC, 26 with limited ETE and 13 with extensive ETE, were included.
  • Funding: None disclosed.

Limitations

  • Retrospective study.
  • Small patient sample size.