- Hypothyroidism was tied to a lower risk for rectal cancer, whereas hyperthyroidism was associated with a lower risk for colon cancer, in a case-control population-based study.
Why this matters
- Colorectal cancer (CRC) is increasingly common: it is the fourth leading cause of death in Taiwan and the third leading cause of death worldwide.
- Mechanistic studies are needed to clarify the inverse association between thyroid disorders and CRC.
- Nationwide population-based case-control study using 2008-2013 data from the Taiwanese National Health Insurance Research Database.
- Thyroid disorder history was compared between new cases of CRC (n=69,713; mean age, 65.8 years) and non-CRC controls (n=69,713; mean age, 66.0 years).
- Funding: None disclosed.
- Hyperthyroidism (adjusted OR [aOR], 0.77; P<.001 and hypothyroidism p=".008)" were associated with a decreased risk for crc.>
- Hypothyroidism in patients aged ≥50 years despite treatment was associated with a 46% decreased risk for rectal cancer (aOR, 0.54; P<.001>
- Hyperthyroidism in all age groups (aOR, 0.74; P<.001 was associated with a lower risk for cancer the strongest inverse association found in those aged years p=".007).</li">
- Case-control design.
- Findings may not generalize to non-Asian populations.
- Predominantly male population (57.2%).