Thyroid disorders tied to lower risk for colorectal cancer

  • L'Heureux A & al.
  • JAMA Netw Open
  • 3 May 2019

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Hypothyroidism was tied to a lower risk for rectal cancer, whereas hyperthyroidism was associated with a lower risk for colon cancer, in a case-control population-based study.

Why this matters

  • Colorectal cancer (CRC) is increasingly common: it is the fourth leading cause of death in Taiwan and the third leading cause of death worldwide.
  • Mechanistic studies are needed to clarify the inverse association between thyroid disorders and CRC.

Study design

  • Nationwide population-based case-control study using 2008-2013 data from the Taiwanese National Health Insurance Research Database.
  • Thyroid disorder history was compared between new cases of CRC (n=69,713; mean age, 65.8 years) and non-CRC controls (n=69,713; mean age, 66.0 years).
  • Funding: None disclosed.

Key results

  • Hyperthyroidism (adjusted OR [aOR], 0.77; P<.001 and hypothyroidism p=".008)" were associated with a decreased risk for crc.>
  • Hypothyroidism in patients aged ≥50 years despite treatment was associated with a 46% decreased risk for rectal cancer (aOR, 0.54; P<.001>
  • Hyperthyroidism in all age groups (aOR, 0.74; P<.001 was associated with a lower risk for cancer the strongest inverse association found in those aged years p=".007).</li">

Limitations

  • Case-control design.
  • Findings may not generalize to non-Asian populations.
  • Predominantly male population (57.2%).

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