Thyroid function linked to BMI, metabolic risk markers

  • Xu R & al.
  • BMC Endocr Disord
  • 7 Jun 2019

  • International Clinical Digest
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Takeaway

  • People with overweight/obese or underweight body mass index (BMI) have altered levels of thyroid hormones, according to a study from China, with associated cardiovascular and metabolic differences.

Why this matters

  • The relationship between thyroid hormone concentrations and body weight is unclear.

Key results

  • Serum free triiodothyronine (fT3) levels and a high fT3/free thyroxine (fT4) ratio were positively associated with BMI, whereas serum fT4 levels were negatively associated with BMI (P<.001 for all in multivariate analysis>
  • fT3 was positively associated with systolic blood pressure (P=.004) and low-density lipoprotein cholesterol (P=.009).
  • fT4 was positively associated with diastolic blood pressure (P<.001 fasting blood glucose and high-density lipoprotein cholesterol negatively associated with hemoglobin a1c p=".017)" triglyceride>
  • fT3/fT4 ratio was positively associated with HbA1c (P=.002) and triglyceride (P<.001 and negatively associated with fasting blood glucose hdl cholesterol>

Study design

  • 16,975 euthyroid subjects admitted to the Health Management Center of Tongji Hospital of Wuhan, China, were analyzed for associations between thyroid function, BMI, and metabolic risk factors.
  • Funding: None.

Limitations

  • Retrospective design.
  • Some confounding factors (smoking, alcohol, diet, physical activity) not captured.