- The thyroid hormones, free thyroxine (fT4) and thyroid-stimulating hormone (TSH), are associated with climacteric symptoms during and after menopause in euthyroid women.
Why this matters
- Climacteric symptoms, a wide variety of symptoms associated with the transition to menopause, are generally linked to decreasing levels of 17β-oestradiol, but are shown here to also be affected by thyroid status.
- Serum fT4 levels were correlated with nervousness (P=.007) and palpitations (P=.04).
- Serum TSH levels were negatively correlated with sweating (P=.03), general weakness (P=.03), and palpitation (P=.02).
- In subgroup analysis, fT4 levels were correlated with general weakness (P=.03), palpitations (P=.009), and paraesthesia (P=.01) in perimenopausal subjects.
- In subgroup analysis, TSH levels were negatively correlated with sweating (P=.03) in postmenopausal women.
- 202 euthyroid women (74 perimenopausal, 128 postmenopausal).
- Funding: None disclosed.
- Retrospective study design.