Thyroid hormone levels linked to climacteric symptoms during/after menopause

  • Slopien R & al.
  • J Endocrinol Invest
  • 7 Aug 2019

  • International Clinical Digest
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Takeaway

  • The thyroid hormones, free thyroxine (fT4) and thyroid-stimulating hormone (TSH), are associated with climacteric symptoms during and after menopause in euthyroid women.

Why this matters

  • Climacteric symptoms, a wide variety of symptoms associated with the transition to menopause, are generally linked to decreasing levels of 17β-oestradiol, but are shown here to also be affected by thyroid status.

Key results

  • Serum fT4 levels were correlated with nervousness (P=.007) and palpitations (P=.04).
  • Serum TSH levels were negatively correlated with sweating (P=.03), general weakness (P=.03), and palpitation (P=.02).
  • In subgroup analysis, fT4 levels were correlated with general weakness (P=.03), palpitations (P=.009), and paraesthesia (P=.01) in perimenopausal subjects.
  • In subgroup analysis, TSH levels were negatively correlated with sweating (P=.03) in postmenopausal women.

Study design

  • 202 euthyroid women (74 perimenopausal, 128 postmenopausal).
  • Funding: None disclosed.

Limitations

  • Retrospective study design.

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