TNBC: racial, age disparities confirmed in largest US database

  • Cancer

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Black women, Hispanic women, and those aged

Why this matters

  • Database covers 99% of US population.
  • TNBC is the most aggressive breast cancer subtype.
  • Findings confirm results of smaller epidemiologic studies and highlight the need for more frequent screening of at-risk populations.

Study design

  • Retrospective, population-based study of 1,151,724 breast cancer cases (2010-2014).
  • Funding: NIH.

Key results

  • TNBC accounted for 8.4% of all breast cancer cases.
  • TNBC likelihood was highest among black (vs white) women (OR, 2.27; 95% CI, 2.23-2.31) and Hispanic women (OR, 1.22; 95% CI, 1.189-2.247 vs white women) in unadjusted analyses.
  • TNBC odds were highest among women
  • TNBC odds were highest among women with stage ≥III cancer by the American Joint Committee on Cancer (stage III: OR, 1.70; 95% CI, 1.675-1.722; stage IV: OR, 1.47; 95% CI, 1.431-1.511) in unadjusted analyses.
  • Results were similar in adjusted analyses.

Limitations

  • Study focused more on stage ≥III tumors with highest morbidity and mortality.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit