- Adjuvant radiation therapy (RT) was not associated with OS benefits in patients with resected primary tracheal carcinoma.
Why this matters
- Adjuvant RT has been used for patients at increased recurrence risk, but its potential benefits for these patients were poorly understood.
- Patients with positive surgical margins (OR, 1.80; 95% CI, 1.06-3.07) and patients with adenoid cystic carcinoma (OR, 6.53; 95% CI, 3.57-11.95 vs squamous cell carcinoma) were more likely to receive adjuvant RT.
- Adjuvant RT was not significantly associated with OS (HR, 1.23 [P=.1782] in multivariate Cox analysis; HR, 0.92 [P=.4969] in propensity score-weighted log-rank test).
- Cancer grade 3/4 (HR, 2.45; P=.0031), surgical margins status (HR, 1.49 [P=.0295] for residual tumor; HR, 1.96 [P=.0002] for not evaluable/unknown), and regional/distant extension (HR 1.44; P=.0141) were associated with poor OS in multivariate analysis.
- Adenoid (HR, 0.32; P<.0001 or other nonsquamous cell histology was associated with improved os in multivariate analysis.>
- 549 patients with resected tracheal cancer, 55% who received RT, from the National Cancer Database (NCDB) were analyzed for survival outcomes.
- Funding: Departmental funding.
- Retrospective study of large database.