- Elderly patients with hypertension who stick to their antihypertensive medication regimen may see a survival benefit even if they also have frailty.
- Patients with good clinical status fare even better, however.
Why this matters
- Although a benefit with good clinical status likely was predictable, the (lesser) benefit for patients with frailty may be a green light for encouraging adherence in this population.
- Clinical status tracked with mortality probability during 7 years:
- 16% with good status vs
- 64% with very poor status.
- The all-cause mortality difference between high adherence (>75% of the time) and low adherence (
- Good: −44%.
- Medium: −43%.
- Poor: −40%.
- Very poor: −33%.
- ORs (95% CIs) for all-cause mortality with >75% adherence, by clinical status:
- Good: 0.56 (0.53-0.60).
- Medium: 0.57 (0.54-0.60).
- Poor: 0.60 (0.58-0.62).
- Very poor: 0.67 (0.63-0.72).
- Data from Lombardy Region of Italy database covering 1,283,602 residents age ≥65 (mean age, 76) years with ≥3 antihypertensive prescriptions, 2011-2012.
- Funding: Italian Ministry of Education, University and Research; Italian Ministry of Health.
- Based on database prescription information.
- Some confounding possible, e.g., from “health-seeking behavior” bias among healthier, more adherent patients.