- This meta-analysis found that the use of triclosan-coated sutures was significantly associated with a reduction in the risk for surgical site infections (SSIs) following closure of a surgical wound compared with standard sutures.
Why this matters
- SSIs are common and serious complications of all surgical interventions.
- Meta-analysis of 25 randomised controlled trials (n=11,957); 6008 patients randomly assigned to triclosan-coated sutures and 5949 to non-triclosan-coated sutures.
- Outcome: development of SSIs at 30 days post-operatively.
- Funding: None.
- There were 420 and 581 instances of SSI in the triclosan-coated and standard suture groups, respectively.
- The risk of developing SSI was significantly lower in the triclosan group vs standard suture groups (relative risk [RR], 0.73; 95% CI, 0.65-0.82; I2=17%).
- Sensitivity analysis revealed that triclosan-coated sutures vs standard sutures were associated with a significantly lower risk for SSI in:
- clean surgery (RR, 0.71; 95% CI, 0.58-0.88), and
- contaminated surgery (RR, 0.43; 95% CI, 0.27-0.7).
- Heterogeneity among included studies.