- Patients previously treated with antibiotics for UTIs are more likely to develop serious infections after transrectal ultrasound (TRUS)-guided prostate biopsy.
Why this matters
- Infection is the most dangerous adverse event after TRUS biopsy, and anticipating and minimizing this risk is important.
- Researchers studied patients who underwent TRUS biopsy (N=590; median age, 69 years; age range, 39-91 years).
- Funding: None disclosed.
- 530 patients (89.8%) received standard prophylaxis of ciprofloxacin monotherapy before TRUS biopsy.
- 74 (12.5%) had previously received intravenous broad-spectrum antibiotics.
- 261 (44.2%) had previously received other antibiotics.
- 37 (6.1%) were hospitalized after biopsy with symptoms of infection.
- Patients previously exposed to narrow-spectrum oral antibiotics were most likely to be hospitalized after biopsy (OR, 2.56; 95% CI, 1.27-5.42; P=.01).
- The study was retrospective and conducted at a single center in Denmark; results may not apply to other populations.
- Researchers may have underestimated antibiotic exposures because of handwritten prescriptions.