- In patients with type 2 diabetes mellitus (T2DM) and without cardiovascular disease (CVD), higher haemoglobin glycation index (HGI) was associated with a higher risk for cardiovascular (CV) events whereas in those with T2DM and CVD, myocardial infarction (MI) risk was lower with higher HGI.
- As glycated haemoglobin (HbA1c) confers similar risk and given the strong correlation between both HGI and HbA1c, additional benefit of using HGI as a risk factor for CV events is most likely limited.
Why this matters
- HGI has been proposed as a marker of inter-individual differences in haemoglobin glycosylation.
- Previous studies have demonstrated an association between high HGI and CVD risk in patients with diabetes. However, no studies have investigated the role of previous CVD in this association
- This study included 1910 patients with T2DM, who participated in the Second Manifestations of Arterial Disease (SMART) study.
- Primary outcomes: major adverse cardiovascular events (MACEs; MI, stroke, retinal infarction, and terminal heart failure).
- Secondary outcomes: total mortality, CV mortality, MI and stroke.
- Funding: None disclosed.
- After adjustment for confounders, higher HGI was associated with increased risk for MACEs in patients without CVD (HR, 1.29; 95% CI, 1.06-1.57; P<.05 but not in those with previous cvd ci>
- Similarly, higher HbA1c was associated with increased risk for MACEs in patients without CVD (HR, 1.23; 95% CI, 1.04-1.45; P<.05 but not in those with previous cvd ci>
- No association observed between HGI, HbA1c and total mortality, CV mortality, MI and stroke.
- The predicted HbA1c was based on the only one fasting plasma glucose measurement.