This site is intended for UK healthcare professionals
Medscape UK Univadis Logo
Medscape UK Univadis Logo
Clinical Summary

Type 2 diabetes: high haemoglobin glycation index predicts cardiovascular disease

Takeaway

  • High haemoglobin glycation index (HGI) was independently associated with incident cardiovascular diseases in patients with type 2 diabetes mellitus (T2DM).
  • Findings support the use of HGI as a marker in addition to HbA1c for prediction of vascular complications in patients with T2DM.

Why this matters

  • Recent studies demonstrate persistently lower or higher than expected HbA1c levels despite similar blood glucose levels in some individuals and ethnic groups, stressing on need for another prognostic marker.

Study design

  • This prospective hospital-based cohort study evaluated prognostic significance of high HGI for cardiovascular disease in 1302 patients with T2DM.
  • Funding: National Research Foundation of Korea.

Key results

  • In a median follow-up of 11.1 years, 17.2% patients were newly diagnosed with cardiovascular disease.
  • Baseline HGI was significantly higher in participants with incident cardiovascular diseases vs those without (P<.001), although baseline levels of fasting blood glucose were similar (P=.465).
  • Risk of developing cardiovascular disease was significantly higher in highest vs lowest quartiles of HGI (aHR, 1.94; 95% CI, 1.31–2.87).
  • Patients in highest vs lowest quartile of HbA1c had a higher risk for cardiovascular diseases (aHR, 1.78; 95% CI, 1.20–2.65); however, HR’s were similar to or lower than those seen for HGI. Effect disappeared after adjusting for HGI.

Limitations

  • Fasting blood glucose was used to calculate HGI.
  • HbA1c and fasting blood glucose levels were measured in patients receiving different types of antidiabetic treatments.

References


YOU MAY ALSO LIKE