- Arterial stiffness index increased in patients diagnosed with chronic inflammation disorder (ID) including rheumatoid arthritis and psoriasis.
- An increasing trend was observed for arterial stiffness with higher tertiles of different inflammatory biomarkers.
- ID biomarkers might have a possible role in discriminating patients with IDs into different risk categories for future cardiovascular diseases.
Why this matters
- Existing evidence supports addition of measures of inflammatory biomarkers to traditional cardiovascular risk scores for improved predictive values.
- However, authors call for further confirmation from prospective studies.
- Study evaluated 171,125 adults (age, 40-69 years) from UK Biobank who were free from cardiovascular diseases.
- 5976 adults were diagnosed with an ID, whereas 165,149 were diagnosed without.
- Funding: None disclosed.
- Chronic IDs vs no IDs was associated with a 14% increase in mean arterial stiffness (adjusted exponentiated coefficient [β], 1.14; P=.002).
- Arterial stiffness increased from 11% (P=.162) in the first tertile to 17% (P=.029) in second and 21% (P=.009) in third tertile of leucocyte count.
- Arterial stiffness increased within rheumatoid arthritis (β, 1.18; P=.044) and psoriasis (β, 1.21; P=.016), but not IBDs (β, 1.14; P=.091).
- Risk for misclassification bias as UK Biobank data are based on self-reported chronic IDs.