UK Biobank study links chronic inflammatory disorders and arterial stiffness

  • Heart

  • from Antara Ghosh
  • Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Arterial stiffness index increased in patients diagnosed with chronic inflammation disorder (ID) including rheumatoid arthritis and psoriasis.
  • An increasing trend was observed for arterial stiffness with higher tertiles of different inflammatory biomarkers.
  • ID biomarkers might have a possible role in discriminating patients with IDs into different risk categories for future cardiovascular diseases.

Why this matters

  • Existing evidence supports addition of measures of inflammatory biomarkers to traditional cardiovascular risk scores for improved predictive values.
  • However, authors call for further confirmation from prospective studies.

Study design

  • Study evaluated 171,125 adults (age, 40-69 years) from UK Biobank who were free from cardiovascular diseases.
  • 5976 adults were diagnosed with an ID, whereas 165,149 were diagnosed without.
  • Funding: None disclosed.

Key results

  • Chronic IDs vs no IDs was associated with a 14% increase in mean arterial stiffness (adjusted exponentiated coefficient [β], 1.14; P=.002).
  • Arterial stiffness increased from 11% (P=.162) in the first tertile to 17% (P=.029) in second and 21% (P=.009) in third tertile of leucocyte count.
  • Arterial stiffness increased within rheumatoid arthritis (β, 1.18; P=.044) and psoriasis (β, 1.21; P=.016), but not IBDs (β, 1.14; P=.091).

Limitations

  • Risk for misclassification bias as UK Biobank data are based on self-reported chronic IDs.