- Joint guidelines from the British Society of Gastroenterology, the Association of Coloproctology of Great Britain and Ireland, and the United Kingdom Cancer Genetics Group define risk categories and cover a wide range of conditions.
Why this matters
- Updates 2010 guidelines, but focuses on those with heightened lifetime risk because of hereditary factors.
- Risk categories:
- Average risk: no family history of colorectal cancer (FHCC) or a FHCC that does not match the moderate- or high-risk categories.
- Moderate risk: FHCC with 1 first-degree relative (FDR) diagnosed at age
- High risk: ≥3 FDRs with CRC at any age spread across ≥2 generations. The individual must be an FDR to at least 1 individual.
- Key recommendations cover: service provision, communication, and management; managing individuals with a family history of CRC, including preventive strategies and lifestyle modifications; and advanced endoscopic imaging in colonic surveillance.
- Testing and management recommendations for individual syndromes, including Lynch syndrome, Lynch-like syndrome, early-onset CRC, serrated polyposis syndrome, patients with multiple colorectal adenomas, familial adenomatous polyposis, MUTYH-associated polyposis, Peutz-Jeghers syndrome, and juvenile polyposis syndrome.