- Administering inactivated influenza vaccine to pregnant women prevents laboratory-confirmed influenza infection, hospitalizations in infants aged
- Related editorial.
Why this matters
- Encourage inactivated influenza vaccine uptake in pregnant women to prevent infant influenza, influenza-related hospitalizations.
- Reinforce that maternal vaccination protects young infants through transplacental antibody transfer.
- 37 infants had confirmed influenza in 2013-2014 and 81 did in 2014-2015.
- 19% and 25% had vaccinated mothers in these respective time frames.
- Overall vaccine uptake was 45.2% and 49.2% for these years.
- Vaccine effectiveness (VE) was 70% (95% CI, 26%-88%) in 2013-2014 and 50% (95% CI, 12%-78%) in 2014-2015.
- By strain: in 2014-2015, VE was 50% (95% CI, 11%-72%), antigenetically/genetically mismatched, A(H3N2)-dominant vs in 2013-2014, when VE was 66% (95% CI, 18%-84%), matched A(H1N1)pdm09-dominant.
- Overall VE adjusted for week, season, region, ethnicity was 66% (P=.46).
- Retrospective cohort analysis reassessing maternal seasonal influenza vaccination for preventing influenza, influenza-related hospitalizations in UK infants aged
- Database: Clinical Practice Research Datalink pregnancy registry.
- Funding: National Institute for Health Research.
- Residual confounding.
- VE covariates limited by data availability.