- Patients aged ≤20 years with ulcerative colitis (UC) in the current era of TNFα inhibitors are at reduced risk for colectomy within 5 years of diagnosis.
- Most treated with anti-TNFα therapy stopped using corticosteroids after 12 months.
Why this matters
- Anti-TNFα therapy may allow postponing colectomy, potentially an important treatment outcome for adolescents who are highly focused on body composition and appearance.
- Researchers analyzed the health records of patients diagnosed with UC either before or after the advent of anti-TNFα therapy (N=3001; age range, 0-20 years).
- Funding: The Beckett Foundation; Danish Colitis and Crohn's Foundation; Region of Southern Denmark; University of Southern Denmark.
- The 5-year cumulative colectomy rate was 12.3% (95% CI, 10.4%-14.6%) in the pre-anti-TNFα group vs 9.7% (95% CI, 8.4%-11.1%) after the introduction of TNFα.
- 5-year aHR, 0.76 (95% CI, 0.60-0.96).
- Corticosteroid treatment declined during follow-up after 6 months (5.4%) and 12 months (1.2%).
- Retrospective design.