Ulcerative colitis: faecal microbiota transplantation with anaerobically prepared stool


  • Mary Corcoran
  • Univadis Medical News
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Findings from a new trial suggest that short-term faecal microbiota transplantation (FMT) using anaerobically prepared pooled stool suspension could be beneficial in patients with ulcerative colitis (UC). 

The randomised controlled trial (RCT) included 73 adults with mild to moderately active UC enrolled across 3 Australian tertiary referral centres between June 2013 and June 2016, with a 12-month follow-up. 

Thirty-eight patients were randomly assigned to receive anaerobically prepared pooled donor FMT, whereas 35 received autologous FMT via colonoscopy, followed by 2 enemas over 7 days. The primary outcome was steroid-free remission of UC, defined as a total Mayo score of ≤2 with an endoscopic Mayo score of ≤1 at week 8. 

Sixty-nine participants completed the trial. The primary outcome was achieved in 32% of participants receiving pooled donor FMT compared with 9% receiving autologous FMT. A total of 42% of participants who achieved the primary endpoint at week 8 following donor FMT maintained remission at 12 months. 

Although the findings suggest anaerobically prepared FMT may be effective in treating UC, the authors said further research is needed to assess longer-term efficacy and safety.

The research is published in JAMA. 

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