Ulcerative colitis tied to higher risk for prostate cancer

  • Ge Y & al.
  • Prostate Cancer Prostatic Dis
  • 7 Oct 2019

  • International Clinical Digest
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Takeaway

  • Ulcerative colitis (UC) is tied to a significantly elevated risk for prostate cancer, but the underlying mechanism is unclear.

Why this matters

  • Increased surveillance may reduce prostate cancer incidence and mortality in men with UC.

Study design

  • Researchers analysed 6 cohort studies (n=86,137) and 3 case-control studies (n=22,760/300,851) reporting prostate cancer outcomes in patients with IBD.
  • Endpoints included pooled standardised incidence ratios (SIRs) or relative risks (RRs) for prostate cancer.
  • Funding: Chinese Ministry of Education; Jiangnan University.

Key results

  • The pooled SIR for cohort studies was 1.33 (95% CI, 1.03-1.71).
  • Subgroup analysis showed higher prostate cancer risk in patients with UC (pooled SIR, 1.58; 95% CI, 1.08-2.30), but not Crohn's disease (pooled SIR, 1.12; 95% CI, 0.97-1.31).
  • In case-control studies, the pooled RR for prostate cancer in IBD was 1.81 (95% CI, 1.43-2.29).

Limitations

  • Analysis did not account for confounders such as family history of prostate cancer.
  • Mechanism of effect unknown.