- Multiple infections trigger acute ischemic stroke (AIS), but urinary tract infection (UTI) carried the greatest magnitude (5-fold) of increased risk.
- Across all infection types, greatest stroke potential was within short time window.
- Preceding UTI, respiratory tract infection, sepsis significantly increased risk for intracerebral hemorrhage (ICH).
- Only respiratory tract infection appeared to increase risk for subarachnoid hemorrhage (SAH).
Why this matters
- Consider potential interventions to address infections and obviate thrombosis, bleeding risks on admission (e.g., intensive thrombotic treatment, specific antibiotic regimens).
- Ensure that patients are up to date on relevant vaccinations.
- Admissions: AIS (n= 152,356), ICH (n=27,257), SAH (n=11,853).
- UTI associated with ≥5 times magnitude for AIS at 7 days' time window (OR=5.32, P<.0001>
- Corresponding risk magnitude decreased with longer time window for all infections.
- ICH: UTI (OR, 1.80 at 14 days; P=.0351), septicemia (OR, 3.25 at 60 days; P=.0393), respiratory tract infection (OR, 2.11 at 7 days; P=.009).
- Only respiratory tract infection was linked to increased ICH risk, highest at 14 days (OR, 3.67; P=.0048).
- Case crossover analysis of differential associations between various infections and risk for AIS, ICH, SAH.
- Funding: None disclosed.
- Classification bias.
- Limited to admitted patients.