Vaccination rates lag in preemies vs full-term infants

  • Hofstetter AM et al
  • Pediatrics
  • 8 Aug 2019

  • International Clinical Digest
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Takeaway

  • Preterm infants (34-36 weeks' gestation) have lower receipt of recommended vaccinations by age 19 months and fail to catch up by 36 months.

Why this matters

  • Familiarity with recommended vaccination schedules, including exclusions, is essential.
  • Communication with parents, understanding health care use patterns to drive catch-up vaccination are recommended.

Key results

  • Among 10,367 infants, ~20% were born prematurely, ~16.6% had low birth weight (
  • 47.5% vs 54.0% preterm, term infants, respectively, completed the 7-vaccine series by 19 months (aOR, 0.77; P<.001 vs by months>
  • Higher percentage of preterm vs term infants missed doses.
    • 16.5% vs 13.8% missed 1 dose (P=.002).
    • 21.2% vs 18.8% missed ≥4 doses (P=.02).
  • Late preterm infants had lowest influenza vaccination rates.
  • Rotavirus coverage was also lower among preterm vs term/postterm infants; early preterm infants had especially low hepatitis B, rotavirus coverage.

 Study design

  • Retrospective cohort study comparing early children vaccinations between preterm, term/postterm infants from 2008 to 2013.
  • Funding: None disclosed.

Limitations

  • Data underreported.
  • Preterm status misclassification.
  • Limited generalizability.
  • Missing confounders.

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