- Overall herpes zoster (HZ) risk among vaccinated children is significantly lower than in unvaccinated children.
- HZ incidence lower in children who received 2 varicella vaccine doses vs 1.
Why this matters
- Continue to encourage varicella zoster virus (VZV) vaccine, schedule completion in all pediatric patients during routine visits.
- 6,372,067 children (3,186,732 vaccinated, 3,185,335 unvaccinated).
- Proportion with ≥1 dose ranged from 52%-82% in 2003 to 91% in 2014.
- HZ incidence was 78% lower vs unvaccinated (38/100,000 person-years [PY] vs 170/100 000 PY, respectively; 82% lower with laboratory-confirmed adjusted rate; P<.0001>
- Overall HZ incidence rate declined by 72% in 2003-2014 (P<.0001 and was consistently lower in vaccinated vs unvaccinated children>
- Among vaccinated children ages 1-2 years, confirmation-adjusted HZ rates: 70% higher vs unvaccinated (P<.0001 remaining significantly lower in older age groups>
- Crude HZ incidence in vaccinated children aged ≥4 years: 28.47 cases/100,000 PY, 14.11 cases/100,000 PY, 1 vaccine dose, 2 doses, respectively (P<.0001>
- Epidemiological analysis of HZ incidence in children ages
- Funding: CDC.
- Historical, prevaccine-era HZ data lacking.
- Prior serological, medical, PCR/culture-confirmed VZV data missing.
- Coding bias.