- This meta-analysis suggests that in patients with diabetes, vitamin D supplementation significantly reduced high-sensitivity C-reactive protein (hs-CRP) and malondialdehyde (MDA) levels (markers of inflammation and oxidative stress, respectively).
- Vitamin D supplementation significantly increased nitric oxide (NO), total antioxidant capacity (TAC) and total glutathione (GSH) levels.
Why this matters
- Previous studies have shown that vitamin D intake may reduce inflammatory response and oxidative stress.
- There are inconsistent results that patients with low vitamin D levels have high levels of inflammatory and oxidative stress biomarkers that have been shown high in people with low vitamin D levels; however, the reports have been inconsistent.
- Meta-analysis of 33 randomised controlled trials (n=1053) identified after a search across MEDLINE, EMBASE, Web of Science and Cochrane databases.
- Funding: Shiraz University of Medical Sciences.
- Vitamin D supplementation significantly reduced serum hs-CRP levels (weighted mean difference [WMD], −0.27; P<.001 and increased no levels p in patients with diabetes.>
- In patients with diabetes, vitamin D supplementation showed a significant reduction in serum MDA levels (WMD, −0.43; P<.001 and a significant increase in tac p gsh levels.>
- Unable to assess the dose-response association between supplementation and inflammation and oxidative biomarkers.
- Publication bias; small sample size.