- Results from a Korean population study suggest that vitiligo is associated with reduced risk for internal malignancies, particularly colorectal, ovarian, and lung cancers.
Why this matters
- It is hypothesized that autoimmune diseases such as vitiligo may increase immune surveillance throughout the body, targeting the development of cancer.
- Patients with vitiligo had reduced incidence of internal malignancies compared with control subjects (612.9 vs 708.9 per 100,000 person-years; HR, 0.86; P<.001 style="list-style-type:circle;">
- HR, 0.79 (95% CI, 0.74-0.85) in men.
- HR, 0.91 (95% CI, 0.86-0.95) in women.
- HR, 0.77 (95% CI, 0.67-0.88) in patients 20-39 years old.
- HR, 0.83 (95% CI, 0.78-0.89) in patients 40-59 years old.
- HR, 0.91 (95% CI, 0.86-0.97) in patients aged 60 years or older.
- 101,078 patients with vitiligo and 202,156 control patients without vitiligo from the Korean National Health Insurance claims database were included.
- Funding: None disclosed.
- Retrospective study design.