Water vapor thermal therapy: a new first-line treatment for LUTS?

  • McVary KT & al.
  • Urology
  • 21 Jan 2019

  • curated by Craig Hicks
  • Clinical Essentials
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Takeaway

  • Water vapor thermal therapy (Rezūm) provides effective symptom relief for lower urinary tract symptoms (LUTS) for more than 4 years in men with benign prostatic hyperplasia (BPH).

Why this matters

  • Symptomatic men with moderate-to-severe LUTS could consider this therapy as a low-risk option to a lifelong commitment to pharmacological management with less-than-optimal outcomes, the investigators say.

Study design

  • Researchers studied men with LUTS secondary to BPH who were treated with thermal therapy and followed for 4 years (n=188; age, ≥50 years old; international prostate symptom score [IPSS], ≥13; peak urinary flow rate [Qmax], ≤15 mL/second; prostate volume 30-80 cc).
  • Funding: NxThera, Inc.

Key results

  • At 3 months, IPSS was reduced by 50% in the treatment group vs 20% in the control group (P<.0001>
  • Within ≤3 months after therapy, LUTS significantly improved (percent improvement):
    • IPSS, 46.7%;
    • QoL score, 42.9%;
    • Qmax, 49.5%;
    • BPH Impact Index, 52.2% (P<.0001>.
  • Results remained consistently durable throughout follow-up.
  • Surgical retreatment rate was 4.4%.
  • Adverse events were infrequent and mild to moderate in severity.
  • Patients reported no disturbances in sexual function.

Limitations

  • The study was unblinded at 3 months.

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