- Water vapor thermal therapy (Rezūm) provides effective symptom relief for lower urinary tract symptoms (LUTS) for more than 4 years in men with benign prostatic hyperplasia (BPH).
Why this matters
- Symptomatic men with moderate-to-severe LUTS could consider this therapy as a low-risk option to a lifelong commitment to pharmacological management with less-than-optimal outcomes, the investigators say.
- Researchers studied men with LUTS secondary to BPH who were treated with thermal therapy and followed for 4 years (n=188; age, ≥50 years old; international prostate symptom score [IPSS], ≥13; peak urinary flow rate [Qmax], ≤15 mL/second; prostate volume 30-80 cc).
- Funding: NxThera, Inc.
- At 3 months, IPSS was reduced by 50% in the treatment group vs 20% in the control group (P<.0001>
- Within ≤3 months after therapy, LUTS significantly improved (percent improvement):
- IPSS, 46.7%;
- QoL score, 42.9%;
- Qmax, 49.5%;
- BPH Impact Index, 52.2% (P<.0001>.
- Results remained consistently durable throughout follow-up.
- Surgical retreatment rate was 4.4%.
- Adverse events were infrequent and mild to moderate in severity.
- Patients reported no disturbances in sexual function.
- The study was unblinded at 3 months.