- Although weight gain might increase Afib risk, nonsurgical weight loss seems to have little effect, according to this meta-analysis.
Why this matters
- With obesity prevalence increasing, avoiding weight gain might be the best approach to Afib risk reduction, rather than trying to lose weight after the fact.
- Pooled data from 10 studies including 108,996 people.
- With 5% weight gain:
- Afib incidence increased by 13%;
- HR, 1.13 (95% CI, 1.04-1.23; 95% prediction interval, 0.88-1.44);
- I2, 70%; n>20,411 in 5 studies, unknown in 1; and
- Most participants had overweight or obesity at the outset.
- With 5% weight loss:
- No change in Afib incidence;
- HR, 1.04 (95% CI, 0.94-1.30; prediction interval, 0.77-1.42); and
- I2, 73%; 5 studies, n=40,704.
- Meta-analysis of 10 studies (9 cohort, 1 randomized controlled trial).
- Outcome: risk for incident Afib relative to weight change.
- Funding: UK National Institute for Health Research.
- Pooling across weight classes might have diluted some estimates.
- High statistical heterogeneity among studies.