- In people who are overweight or have obesity but are metabolically healthy, weight decrease is linked to reduced risk for subclinical carotid atherosclerosis.
Why this matters
- Clinicians can let their patients with BMI outside the normal-weight range know that even with good metabolic measures, losing weight could further decrease their cardiovascular disease (CVD) risk.
- 12,248 person-years of follow-up (median, 3.42 [range, 0.5-8.7] years).
- 47.0% lost no weight or gained weight during follow-up.
- 44.4% lost 0.1%-4.9% of body weight; 8.6% lost 5% or more of body weight.
- Compared with those who lost no weight or who gained some, subclinical carotid atherosclerosis risk decreased with:
- 0.1%-4.9% loss: aHR, 0.84 (95% CI, 0.72-0.98).
- ≥5% loss: aHR, 0.66 (95% CI, 0.50-0.87).
- Those who lost no weight or gained weight tended to be younger and smoke; have lower BMI, body fat, and waist circumference; and have higher low-density lipoprotein cholesterol levels.
- Cohort study, 3117 adults in Korea.
- Atherosclerosis was assessed via carotid artery ultrasonography.
- Outcome: development of subclinical carotid atherosclerosis.
- Funding: None disclosed.
- Reasons for weight reduction were not known.
- Weight change might not have been linear between 2 measurement points.