What are the top 3 endocrine complications in beta-thalassemia intermedia?

Takeaway

• Osteopenia/osteoporosis, hypogonadism, and primary hypothyroidism are the most common endocrine complications in patients with beta-thalassemia intermedia (β-TI).

Why this matters

• Data on the prevalence and type of endocrine disorders are limited in this patient group.

Key results

• The most prevalent complications were osteopenia/osteoporosis (26.2%), hypogonadism (9.8%), and primary hypothyroidism (5.2%).
• Age >35 years was associated with osteoporosis (OR, 7.870; P<.001), hypogonadism (OR, 6.310; P<.001), and noninsulin-dependent diabetes mellitus (OR, 17.67; P=.007).
• Splenectomy was associated with osteoporosis (OR, 1.736; P=.045).
• Hydroxyurea was associated with reduced risk for noninsulin-dependent diabetes mellitus (OR, 0.259; P=.034).

Study design

• 522 patients with β-TI were analyzed for endocrine disorders and associated risk factors.
• Funding: None disclosed.

Limitations

• A cross-sectional study with a heterogeneous patient population.