- Women with hypertensive disorders of pregnancy have higher risk for cardiovascular disease (CVD), and traditional CVD risk factors are to blame.
- BMI and BP are crucial players in explaining the excess CVD risk in these patients, who do not experience increased risk after age 70 years.
Why this matters
- What underlies the increased CVD risk for women with hypertensive disorders of pregnancy has been unclear.
- At ages 40-70 years, women with a history of hypertensive disorders of pregnancy had increased CVD risk vs women with normotensive pregnancies: HR, 1.57 (95% CI, 1.32-1.86).
- However, this increased risk did not hold up at older ages.
- BP, BMI explained 77% of the excess risk seen in women with hypertensive disorders of pregnancy.
- Glucose (25%), lipid levels (24%) explained less of the increase.
- Little difference between types of pregnancy-related hypertension.
- Specific increased risks for women ages 40-70 years (HRs; 95% CIs):
- Myocardial infarction: 1.86 (1.40-2.48),
- Heart failure: 1.59 (0.92-2.73), and
- Cerebrovascular events: 1.47 (1.15-1.87).
- Prospective Norwegian cohort registry study of 23,885 women (2119 with hypertensive disorders of pregnancy at age
- Funding: Research Council of Norway, others.
- Usual limitations of registry data.