- In older adults, advanced age, female sex, and use of certain drugs predict fragility fracture risk within the next year (imminent fracture).
Why this matters
- Breaking a bone increases mortality risk for up to 10 years thereafter.
- Knowledge of risk factors can tailor treatment and patient education.
- Retrospective cohort study using administrative claims data from Humana's Medicare Advantage and Prescription Drug plan for 1.287 million older US adults.
- Analysis focused on the incidence of nontraumatic clinical fractures in the first 12 months starting in 2015.
- Funding: None disclosed.
- 3.8% of cohort had ≥1 fragility fracture at 12-month follow-up and 6.6% at 24 months.
- Over the 12-month period, the following factors were associated (adjusted HRs) with having any type of fracture (all P<.0001 unless noted otherwise>
- Recent fracture: 2.81.
- Age 85-87 years: 2.21.
- Age 80-84 years: 1.78.
- Female sex: 1.46.
- Age 75-79 years: 1.44.
- Antidepressant/antipsychotic/sedative hypnotic/muscle relaxant medications: 1.30.
- Respiratory disorders: 1.25.
- Falls: 1.24.
- White race: 1.16 (P=.0042).
- Cerebrovascular disorders: 1.12.
- Age 70-74 years: 1.11.
- Retrospective observational design.
- Reliance on administrative claims data.