- Risk factors for distant metastasis in high-risk triple-negative breast cancer (TNBC) are positive lymph nodes and lymphovascular space invasion (LVSI).
- High-risk is defined as failing to achieve pathologic complete response (pCR) after treatment with neoadjuvant chemotherapy (NAC).
Why this matters
- Results suggest a way to stratify patients with high-risk TNBC in relation to their prognosis and to design future clinical trials.
- Retrospective cohort study (153 consecutive patients) of high-risk TNBC at a single-center (treated with NAC, surgery, and radiation therapy).
- Funding: None disclosed.
- Median follow-up was 4.04 (range, 0.51-13.97) years.
- 29.4% of the cohort achieved pCR after NAC; the remainder did not.
- Comparing 5-year freedom from distant metastasis between patients without pCR (55%) vs with pCR (98%), the following 2 risk factors independently predicted distant metastatic disease:
- Positive lymph nodes: HR, 3.08 (P=.001).
- LVSI: HR, 1.91 (P=.030).
- Retrospective, observational design.
- Small cohort.