What's the effect of poor sleep quality on cognitive decline?

  • Lee JE & al.
  • J Affect Disord
  • 28 Aug 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • This study suggests that poor sleep quality might contribute to subjective cognitive decline (SCD) and SCD-related functional limitation.
  • The effect of sleep quality on SCD and SCD-related functional limitation might be greater in younger vs older adults.

Why this matters

  • Findings suggest that intervention programmes are required for the prevention of poor sleep quality and cognitive decline in both younger and older adults

Study design

  • Study used cross-sectional data (n=203,082; aged ≥19 years) to evaluate the association between sleep quality and cognitive decline.
  • Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and responses were categorised as good sleep quality (score of 0-5) and poor sleep quality (score of ≥6).
  • Funding: None.

Key results

  • Overall, 35,892 (17.7%) patients had SCD and 4373 (2.2%) patients had SCD-related functional limitation.
  • Individuals with poor sleep quality (PSQI>5) vs those without (PSQI≤5) had a significantly higher risk for:
    • SCD (OR, 1.983; 95% CI, 1.915-2.054) and
    • SCD-related functional limitation (OR, 2.405; 95% CI, 2.158-2.681).
  • Younger vs older adults showed a greater effect of poor sleep quality on SCD and SCD-related functional limitation.
    • 19-29 years (OR, 3.368; 95% CI, 2.835-4.002 and OR, 2.634; 95% CI, 1.529-4.539),
    • 30-39 years (OR, 2.570; 95% CI, 2.284-2.893 and OR, 3.784; 95% CI, 2.516-5.691),
    • 40-49 years (OR, 2.054; 95% CI, 1.880-2.244 and OR, 3.660; 95% CI, 2.575-5.203),
    • 50-59 years (OR, 1.850; 95% CI, 1.720-1.989 and OR, 2.170; 95% CI, 1.605-2.933) and
    • 60-69 years (OR, 1.843; 95% CI, 1.716-1.979 and OR, 2.997; 95% CI, 2.317-3.877).

Limitations

  • Retrospective self-reported data.
  • Cross-sectional data could not establish a causal association.

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