- In patients aged 80 years or more who have had a first myocardial infarction (MI), statins may be appropriate if their 2-year mortality risk is low.
Why this matters
- Observational data suggest that statins in this older age group offer limited benefits following a first MI, but the study designs have limited the scope of the findings.
- Statins for 2 years were tied to reduced risk for composite of recurrent MI, stroke, and cardiovascular mortality: aHR, 0.81 (95% CI, 0.66-0.99).
- All-cause mortality risk was also decreased in this group: aHR, 0.84 (95% CI, 0.73-0.97).
- To prevent the composite outcome in 1 patient during the 4.5 years of median follow-up, 59 patients had to be treated.
- To prevent a death, 39 patients had to be treated.
- Correcting for deaths in the first 2 years of this period raised both the values.
- Retrospective cohort study, 9020 patients, 3900 older than 80 years.
- 2 years of statin prescriptions were compared with no statin or less than 2 years of statins.
- Funding: None.
- Unmeasured confounding is likely.
- Not known if the patients took the prescribed statins.