Which probiotic is best for irritable bowel syndrome with diarrhoea?

  • Liang D & al.
  • Medicine (Baltimore)
  • 1 Jul 2019

  • International Clinical Digest
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Takeaway

  • The best probiotic treatment for irritable bowel syndrome with diarrhoea (IBS-D) is a combination of Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophilus.

Why this matters

  • Patients commonly use probiotics to reduce IBS symptoms, sometimes after consulting doctors or pharmacists, but few studies compare the efficacy and safety of different probiotic treatments.

Study design

  • Researchers performed a network meta-analysis of 14 randomised controlled trials comparing the effects of 5 different probiotic treatments with placebo (N=1695).
  • Funding: None disclosed.

Key results

  • More patients reported adequate or satisfactory relief from IBS-D symptoms with DUO than other treatments when compared with placebo (risk ratio, 7.46; 95% CI, 2.00-32.23).
  • Adverse events included mild, transient gastrointestinal symptoms, with no significant differences between treatment and placebo groups.

Limitations

  • Some included studies had small sample sizes; all had different treatment durations, and none provided direct comparisons of different probiotic treatments.

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