- The best probiotic treatment for irritable bowel syndrome with diarrhoea (IBS-D) is a combination of Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophilus.
Why this matters
- Patients commonly use probiotics to reduce IBS symptoms, sometimes after consulting doctors or pharmacists, but few studies compare the efficacy and safety of different probiotic treatments.
- Researchers performed a network meta-analysis of 14 randomised controlled trials comparing the effects of 5 different probiotic treatments with placebo (N=1695).
- Funding: None disclosed.
- More patients reported adequate or satisfactory relief from IBS-D symptoms with DUO than other treatments when compared with placebo (risk ratio, 7.46; 95% CI, 2.00-32.23).
- Adverse events included mild, transient gastrointestinal symptoms, with no significant differences between treatment and placebo groups.
- Some included studies had small sample sizes; all had different treatment durations, and none provided direct comparisons of different probiotic treatments.