Yogurt linked to lower hip fracture risk in meta-analysis

  • Ong AM & al.
  • Adv Nutr
  • 11 Oct 2019

  • International Clinical Digest
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Takeaway

  • A meta-analysis finds that high yogurt intake, but not high cheese intake, in postmenopausal women is associated with lower hip fracture risk compared with low intake.

Why this matters

  • Osteoporosis affects around 200 million women globally.
  • Clinicians should consider recommending high yogurt intake for hip fracture prevention.

Study design

  • Systemic review or meta-analysis of 3 randomized controlled trials, 3 prospective cohorts (n=108,219), and 3 case-control studies after review of Embase, MEDLINE, CINAHL Plus, and CENTRAL.
  • Funding: None.

Key results

  • Among the 3 prospective cohorts, higher yogurt intake was associated with 24% reduced hip fracture risk (pooled relative risk [RR], 0.76; 95% CI, 0.63-0.92; I2=29%).
  • In the same 3 cohorts, high cheese intake was not associated with reduced hip fracture risk (pooled RR, 0.89; 95% CI, 0.73-1.10; I2=0%).
  • A review, but not meta-analysis, of case-control studies found that high cheese intake had either no or a protective effect against osteoporosis (defined as bone mineral density T-score ≤−2.5).
  • A review, but not meta-analysis, of 3 randomized controlled trials found that daily yogurt or cheese intervention lowered bone resorption marker levels, but had no effect on bone formation markers.

Limitations

  • Small number of studies.
  • Moderate heterogeneity.