- A report of 3 patients links positive test results for Zika virus infection with development of Guillain-Barré syndrome (GBS).
Why this matters
- The incidence of GBS has increased 5- to 10-fold in Suriname since the beginning of the Zika outbreak.
- Patient 1, a man in his 40s, reported rash, red eyes, and arthralgia 7 d before GBS onset; he had a negative Zika virus urine real-time quantitative RT-PCR (qRT-PCR) but a positive virus neutralization test and IgG antibodies against the virus in serum.
- Patient 2, another man in his 40s, had influenza-like syndrome and brief diplopia the week before GBS onset; a urine sample tested positive for Zika virus RNA.
- Patient 3, a man in his 60s, had no antecedent symptoms; he had a negative Zika virus urine qRT-PCR but a positive virus neutralization test and IgG antibodies against the virus in serum.
- By 4 mo, 2 patients recovered fully, whereas 1 still could not live independently.
- Case series of 3 patients in Suriname who developed GBS.
- Main outcome was evidence of prior Zika virus infection.
- Funding: Not disclosed.
- Findings are based on just 3 patients.
- Presentations may differ in other populations.