Zika virus linked to infant bladder dysfunction

  • J Pediatr Urol.
  • 30 Apr 2019

  • International Clinical Digest
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Takeaway

  • Neurogenic bladder (NB) is common among babies born with congenital Zika syndrome (CZS) and microcephaly.

Why this matters

  • Without timely intervention, NB can cause irreversible renal damage; lack of awareness about the association between CZS and NB delays investigation and treatment.

Study design

  • Researchers studied babies born with neurological impairment caused by CZS (n=69; mean age, 13.6 months; age range, 2-23 months; 36 girls), evaluating them for NB following International Children’s Continence Society guidelines.
  • Funding: Federal Government of Brazil.

Key results

  • Urodynamic studies for all patients had abnormal results consistent with NB.
  • Most patients (91.3%) had overactive bladder with increased pressures and reduced capacity for age.
  • Only 26 patients (38%) were able to void to completion at the end of the urodynamic studies; 43 (62%) had elevated postvoid residual holding averaging 36% of their measured bladder capacity.

Limitations

  • The cause of NB secondary to CZS remains unclear.
  • The role of Zika virus infection in the urological system is unknown.