Certain factors, such as previous vaginal delivery, can increase risk.

Findings from an early-stage NIHR-funded study.

RCC risk higher with early renal stone diagnosis.

Simplified regimen may boost adherence to mono or dual therapy.

Avoid deferred/intermittent treatment.

FDA and Endocrine Society have warned of increased cardiovascular risk.

Lower-dose clomipramine before coitus can decrease risks and cost.

Higher QoL self-efficacy associated with better adherence.

Physicians should query older individuals about their sexual activity and offer help for sexual difficulties.

More research is needed to determine long-term efficacy and safety.

Data favor single-tablet vs multitablet regimens.

Study examines course and progression over time.

Rates remain roughly 3-fold higher than in the general population.

Patient education sorely needed.