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Latest drug updates

  • 14 Feb 2018 - Drug Updates

Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions

Closely monitor patients and remove the vaginal delivery system immediately in case of excessive or prolonged uterine contractions.

  • 9 Feb 2018 - Drug Updates

Incidence of death and fractures reported with concomitant use of radium-223 dichloride (Xofigo▼) and abiraterone, prednisone/prednisolone

Until full analysis of the results is completed, do not use radium-223 dichloride in combination with abiraterone acetate and prednisone/prednisolone.

  • 9 Feb 2018 - Drug Updates

Use of gadolinium-containing contrast agents like gadodiamide (Omniscan) and intravenous gadopentetic acid (Magnevist) suspended

Use of gadolinium-containing contrast agents limited to delayed phase liver imaging only.

  • 31 Jan 2018 - Drug Updates

Fingolimod (Gilenya▼): Risk of skin cancer, lymphoma and serious opportunistic infections

Monitor patients closely for skin cancers and advise patients to seek urgent attention if they develop signs or symptoms of serious infections.

  • 31 Jan 2018 - Drug Updates

Eluxadoline (Truberzi▼): Risk of pancreatitis and contraindication in patients who have undergone cholecystectomy or with biliary disorders

Instruct patients to stop taking eluxadoline and seek immediate medical attention if pancreatitis symptoms develop.

  • 31 Jan 2018 - Drug Updates

Fingolimod (Gilenya▼): Risk of serious cardiac arrhythmias

New contraindications introduced for use of fingolimod in patients with pre-existing cardiac disorders.

  • 27 Dec 2017 - Drug Updates

Reports of progressive multifocal encephalopathy (PML) post-treatment with Cladribine (Litak, Leustat) for leukaemia

Consider progressive multifocal encephalopathy (PML) in the differential diagnosis for patients with new or worsening neurological signs or symptoms.

  • 18 Dec 2017 - Drug Updates

Inadvertent switching between brands of tacrolimus associated with reports of toxicity and graft rejection

Ensure careful supervision and therapeutic monitoring while switching patient to different brand of tacrolimus products.

  • 18 Dec 2017 - Drug Updates

Quinine: Dose-dependent effects on QT interval and drug interactions

Monitor patients closely if administering quinine with anticonvulsants.

  • 15 Dec 2017 - Drug Updates

Patient-related factors and 3 risk-based categories should be considered while prescribing antiepileptic drugs

Core advice from 2013 remains effective while switching between different manufacturers’ products of an oral antiepileptic drug.