AAD 2019—Bermekimab shows dramatic improvement in pruritus and atopic dermatitis


  • Marielle Fares, Pharm.D.
  • Conference Reports
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Takeaway

  • A multicenter study showed that bermekimab, an anti-IL-1α inhibitor, is an effective treatment of atopic dermatitis (AD) in patients with moderate-to-severe disease refractory to standard therapy.

Why this matters

  • In AD, ruptured keratinocytes produce IL-1α, which induces the inflammatory cascade and potentiates pain perception and pruritus.
  • Bermekimab may represent an important new treatment for pruritus and moderate-to-severe AD.

Key results

  • Bermekimab resulted in statistically significant improvements from baseline in all measures of disease severity after 7 weeks (P<.001 for all>
  • Percentage reductions from baseline in the high-dose 400 mg group:
    • Dermatology Life Quality Index (DLQI) (70%).
    • Eczema Area and Severity Index (EASI) (76%).
    • Global Individual Signs Score (GISS) (54%).
    • Hospital Anxiety and Depression Scale-Anxiety Subscale (HADS-AS) (65%).
    • HADS-Depression Subscale (HADS-DS) (59%).
    • Patient-Oriented Eczema Measures (POEM) (66%).
    • Severity Scoring of Atopic Dermatitis (SCORAD) (64%).
  • 75% of patients had more than 4-point improvement in pruritus Numerical Rating Scale (NRS) worst and average itch scores.
  • EASI 50 (82%).
  • EASI 75 (71%).
  • 25% of patients had more than 2-point improvement in Investigator Global Assessm­­ent (IGA) scores and reache­­d a score of 0-1 by week 7.
  • No new treatment-related adverse events were reported.

Study design

  • 38 patients received subcutaneous bermekimab injections weekly (10 patients received 200 mg for 4 weeks and 28 patients received 400 mg for 8 weeks).
  • Study was an open-label, proof-of-concept, multicenter study.
  • Funding: XBiotech Inc.

Limitations

  • Small number of patients.
  • Not randomized or blinded.
     

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