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Clinical Summary

AB blood type linked to higher CHD risk in women with T2D

Takeaway

  • Women with type 2 diabetes (T2D) who have AB blood type appear to be at elevated coronary heart disease (CHD) risk.

Why this matters

  • Previous findings suggest non-O blood types may raise CHD risk, but the relationship has not been studied in patients with diabetes.

Study design

  • Case-control study of 881 women with T2D including 238 with CHD.  
  • Of the 643 CHD-negative women, 282 were matched with the CHD-positive group for other cardiac risk factors including BP, HbA1c, lipids, thyroid-stimulating hormone, and plasma creatinine.
  • Funding: None disclosed.

Key results

  • AB blood group present in 12.3% with CHD vs 4.7% without (OR, 2.9; P=.001).
  • No significant differences in percentage of other blood groups between CHD+ and CHD− groups (percentage of A vs B in CHD+ and CHD−, P=.304 and .236, respectively).
  • Percentage of non-O types was nonsignificantly higher in CHD group (65% vs 58.2%; P=.104).  
  • Rhesus factor was positive in 92.0% with CHD vs 93.3% without (P=.705).
  • Systolic BP was nonsignificantly higher in AB group (P=.065), no other differences by other cardiac risk factors.

Limitations

  • No data on plasma levels and half-life of von Willebrand factor.
  • Study population all from a single Iranian region.

References


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