Takeaway
- Women with type 2 diabetes (T2D) who have AB blood type appear to be at elevated coronary heart disease (CHD) risk.
Why this matters
- Previous findings suggest non-O blood types may raise CHD risk, but the relationship has not been studied in patients with diabetes.
Study design
- Case-control study of 881 women with T2D including 238 with CHD.
- Of the 643 CHD-negative women, 282 were matched with the CHD-positive group for other cardiac risk factors including BP, HbA1c, lipids, thyroid-stimulating hormone, and plasma creatinine.
- Funding: None disclosed.
Key results
- AB blood group present in 12.3% with CHD vs 4.7% without (OR, 2.9; P=.001).
- No significant differences in percentage of other blood groups between CHD+ and CHD− groups (percentage of A vs B in CHD+ and CHD−, P=.304 and .236, respectively).
- Percentage of non-O types was nonsignificantly higher in CHD group (65% vs 58.2%; P=.104).
- Rhesus factor was positive in 92.0% with CHD vs 93.3% without (P=.705).
- Systolic BP was nonsignificantly higher in AB group (P=.065), no other differences by other cardiac risk factors.
Limitations
- No data on plasma levels and half-life of von Willebrand factor.
- Study population all from a single Iranian region.
References
References