- A combined infusion of glucagon-like peptide-1 (GLP-1), oxyntomodulin, and peptide YY (known as GOP) leads to improved glycemia, body weight reductions.
- Glucose tolerance, variability outcomes best those of gastric bypass, very-low-calorie diet (VLCD).
Why this matters
- One effect of Roux-en-Y gastric bypass (RYGB) is increased levels of GOP, and infusion of GOP reduces energy intake.
- Weight loss was greater with GOP vs saline: mean change, −4.4 (95% CI, −5.3 to −3.5; P=.025).
- GOP-associated weight loss (4% from baseline) was less than with RYGB (8.8%) or VLCD (7.56), however.
- GOP bested RYGB for reducing fasting glucose but did not differ from VLCD.
- Glucose tolerance after mixed-meal stimulus was better with GOP vs either intervention.
- Glycemic variability was also dampened more with GOP vs RYGB or VLCD.
- The infusions were well-tolerated.
- Single-blinded trail of patients with obesity and prediabetes/diabetes.
- 15 had GOP, 11 had saline, each for 4 weeks.
- Authors also analyzed data for 21 patients who had RYGB and 22 on VLCD.
- Outcomes included body weight, glucose tolerance, glucose variability.
- Funding: UK Medical Research Council, others.
- Infused only 12 of 24 hours.
- Small population, short duration.