Takeaway
- Pretreatment neutrophil-to-lymphocyte ratio (NLR) is associated with survival outcomes in advanced nasopharyngeal carcinoma (NPC).
Why this matters
- This study adds support to prior research linking the NLR, a routine blood measurement, to NPC prognosis.
Key results
- Median NLR was 2.27 (interquartile range, 1.71-3.12).
- A cutoff value of 2.50 was identified by receiver operating characteristic analysis.
- NLR >2.50 was associated with reduced 5-year OS (82.5% vs 90.3%; P<.001 distant metastasis-free survival vs and pfs compared with nlr>
- NLR was not significantly associated with locoregional relapse-free survival (P=.309).
- NLR was independently associated with OS (HR, 1.72; P<.001 dmfs and pfs in multivariate analysis.>
- Age and N stage were also associated with OS (HR, 1.69 [P<.001 and respectively pfs in multivariate analysis.>
Study design
- 1550 patients with stage II-IVB NPC were analyzed for pretreatment NLR and associations with survival outcomes.
- Funding: Health and Medical Collaborative Innovation Project of Guangzhou City; National Natural Science Foundation of China.
Limitations
- Retrospective study.
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