Advanced NPC: pretreatment NLR predicts survival outcomes in Chinese study

  • Yao JJ & al.
  • BMC Cancer
  • 8 Jan 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Pretreatment neutrophil-to-lymphocyte ratio (NLR) is associated with survival outcomes in advanced nasopharyngeal carcinoma (NPC).

Why this matters

  • This study adds support to prior research linking the NLR, a routine blood measurement, to NPC prognosis.

Key results

  • Median NLR was 2.27 (interquartile range, 1.71-3.12).
  • A cutoff value of 2.50 was identified by receiver operating characteristic analysis.
  • NLR >2.50 was associated with reduced 5-year OS (82.5% vs 90.3%; P<.001 distant metastasis-free survival vs and pfs compared with nlr>
  • NLR was not significantly associated with locoregional relapse-free survival (P=.309).
  • NLR was independently associated with OS (HR, 1.72; P<.001 dmfs and pfs in multivariate analysis.>
  • Age and N stage were also associated with OS (HR, 1.69 [P<.001 and respectively pfs in multivariate analysis.>

Study design

  • 1550 patients with stage II-IVB NPC were analyzed for pretreatment NLR and associations with survival outcomes.
  • Funding: Health and Medical Collaborative Innovation Project of Guangzhou City; National Natural Science Foundation of China.

Limitations

  • Retrospective study.

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